ADDP and PS-PPh3: an efficient Mitsunobu protocol for the preparation of pyridine ether PPAR agonists
2006
Efficient Method for Making PPAR Agonists
publication
Evidence: high
Author Information
Author(s): Paul S Humphries, Do Quyen-Quyen T, David M Wilhite
Primary Institution: Pfizer Global R&D
Hypothesis
Can a modified Mitsunobu protocol improve the synthesis of pyridine ether PPAR agonists?
Conclusion
The modified Mitsunobu protocol using ADDP and PS-PPh3 resulted in a rapid and high-yielding synthesis of PPAR agonists.
Supporting Evidence
- The method eliminated significant by-product formation.
- The protocol was versatile and efficient.
- High yields were achieved with various alcohols.
Takeaway
Scientists found a better way to make important drugs that help with metabolism and inflammation, using a special chemical reaction.
Methodology
A modified Mitsunobu reaction was used to synthesize pyridine ether PPAR agonists with high yields.
Digital Object Identifier (DOI)
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