Polarised Asymmetric Inheritance of Accumulated Protein Damage in Higher Eukaryotes
2006
Asymmetric Inheritance of Protein Damage in Cell Division
publication
Evidence: high
Author Information
Author(s): Maria Rujano, Harm Kampinga
Hypothesis
Can cells with accumulated damage undergo cell division and complete mitosis?
Conclusion
Cells with accumulated protein damage can still divide and complete mitosis, with one daughter cell inheriting the damage and the other remaining damage-free.
Supporting Evidence
- Cells with severe levels of damage were unable to progress through mitosis.
- In single-aggresome–containing cells, only one daughter cell inherited the damage.
- Time-lapse imaging confirmed that cells with aggresomes take longer to complete mitosis than normal cells.
- Stem cells did not contain aggresomes, while differentiated cells did.
- In Drosophila, the neuroblast daughter cell inherited the aggresome, resulting in a damage-free GMC.
Takeaway
Cells can split into two, and one of them can take all the junk while the other stays clean.
Methodology
The researchers investigated multiple eukaryotic cell systems, including human and hamster cells, and used time-lapse imaging to observe mitosis.
Limitations
The researchers could not verify their hypothesis in the human model due to the absence of mitotic stem cells.
Participant Demographics
Human patients with neurodegenerative disorder and Drosophila embryos.
Digital Object Identifier (DOI)
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