Diabetes and Tuberculosis Treatment Outcomes
Author Information
Author(s): Baker Meghan A, Harries Anthony D, Jeon Christie Y, Hart Jessica E, Kapur Anil, Lönnroth Knut, Ottmani Salah-Eddine, Goonesekera Sunali D, Murray Megan B
Primary Institution: Massachusetts General Hospital
Hypothesis
Does diabetes mellitus negatively impact tuberculosis treatment outcomes?
Conclusion
Diabetes increases the risk of failure and death combined, death, and relapse among patients with tuberculosis.
Supporting Evidence
- Diabetes is associated with an increased risk of failure and death during tuberculosis treatment.
- Patients with diabetes have a risk ratio for the combined outcome of failure and death of 1.69.
- The risk of death during tuberculosis treatment among patients with diabetes is 1.89.
- Diabetes is also associated with an increased risk of relapse with a risk ratio of 3.89.
Takeaway
People with diabetes are more likely to have bad outcomes when they get treated for tuberculosis, which means they might not get better as easily.
Methodology
A systematic review and meta-analysis of observational studies assessing the impact of diabetes on tuberculosis treatment outcomes.
Potential Biases
Potential biases due to confounding factors like age and HIV status were not always controlled for.
Limitations
The studies included were observational and may have biases; many did not specify if diabetes was diagnosed before tuberculosis.
Participant Demographics
Included studies from various countries with diverse populations, primarily adults with tuberculosis and diabetes.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI, 1.36 to 2.12 for failure and death; 95% CI, 1.52 to 2.36 for death; 95% CI, 2.43 to 6.23 for relapse.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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