Assignment of the gene encoding for Meth A tumour rejection antigen (TATA) to Chromosome 12 of the mouse
1984
Gene Encoding for Meth A Tumor Rejection Antigen Assigned to Chromosome 12
Sample size: 24
publication
Evidence: moderate
Author Information
Author(s): L.W. Law
Primary Institution: National Cancer Institute, Bethesda, Maryland, USA
Hypothesis
Can the gene coding for the Meth A antigen be assigned to a specific chromosome?
Conclusion
The study shows a clear correlation between chromosome 12 and Meth A antigen expression.
Supporting Evidence
- Immunization with somatic cell hybrids bearing chromosome 12 led to protection against Meth A sarcoma.
- Only hybrids with the X12 chromosome were capable of immunizing against Meth A challenge.
- Previous studies have shown a relationship between Meth A antigen expression and chromosome 12.
Takeaway
Scientists found that a specific gene related to a tumor in mice is located on chromosome 12, which helps understand how the immune system can recognize and fight the tumor.
Methodology
BALB/c female mice were immunized with somatic hybrid cells and then challenged with Meth A sarcoma to assess tumor rejection.
Participant Demographics
BALB/c female mice, 10-12 weeks of age.
Statistical Information
P-Value
P<0.001, P<0.01
Statistical Significance
p<0.01
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