Jianwei Xiaoshi Oral Liquid Helps with Indigestion in Young Rats
Author Information
Author(s): Zhang Yan, Wei Xiaolu, Jiang Shan, Gao Wenya, Wang Kun, Wang Hongjie, Wang Huijun, Si Nan, Zhou Yanyan, Luo Keke, Wang Mengxiao, Liu Yuyang, Chen Lihua
Primary Institution: China Academy of Chinese Medical Sciences
Hypothesis
The study investigates the efficacy of Jianwei Xiaoshi oral liquid in treating dyspepsia in immature rats through its effects on pancreatic secretion and gut microbiota.
Conclusion
Jianwei Xiaoshi oral liquid improved functional dyspepsia in immature rats by regulating pancreatic secretion and restoring gut microbiota balance.
Supporting Evidence
- JWXS was shown to regulate the secretion of 8 key proteins in the pancreatic secretion pathway.
- The study identified 15 differential bacteria and 16 differential fungi in the gut microbiota.
- JWXS treatment restored levels of short-chain fatty acids that were decreased in the model group.
Takeaway
This study shows that a special herbal medicine can help young rats with tummy troubles by fixing their digestion and helping good bacteria grow in their bellies.
Methodology
The study used pharmacological experiments, transcriptomics, gut microbiota analysis, and metabolomics to evaluate the effects of Jianwei Xiaoshi oral liquid.
Limitations
The study primarily relied on network pharmacology for component identification, and further experimental validation is needed.
Participant Demographics
Immature male Sprague-Dawley rats aged 3-4 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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