Skeletal Muscle Mitochondrial Uncoupling and Cold Induced Thermogenesis
Author Information
Author(s): Sander L. J. Wijers, Patrick Schrauwen, Wim H. M. Saris, Wouter D. van Marken Lichtenbelt
Primary Institution: Maastricht University, The Netherlands
Hypothesis
Cold-induced adaptive thermogenesis in humans is accompanied by an increase in mitochondrial uncoupling in skeletal muscle.
Conclusion
This study shows that human skeletal muscle can increase energy expenditure through mitochondrial uncoupling in response to cold exposure.
Supporting Evidence
- Mild cold exposure increased energy expenditure by 2.8%.
- The increase in energy expenditure correlated with mitochondrial uncoupling.
- No increase in physical activity was observed during cold exposure.
Takeaway
When it's cold, our muscles can help us burn more energy, which might help with weight control.
Methodology
The study measured energy expenditure and mitochondrial uncoupling in 11 lean male subjects during mild cold exposure and baseline conditions.
Limitations
The study only included lean male subjects, which may limit the generalizability of the findings.
Participant Demographics
Eleven lean male subjects, average age 21.7 years, BMI 22.9 kg/m2.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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