Resveratrol Reduces Mammary Cancer in Rats
Author Information
Author(s): Timothy Whitsett, Mark Carpenter, Coral A Lamartiniere
Primary Institution: University of Alabama at Birmingham
Hypothesis
Do resveratrol and EGCG protect against chemically-induced mammary cancer by modulating mammary gland architecture, cell proliferation, and apoptosis?
Conclusion
Resveratrol in the diet can reduce susceptibility to mammary cancer, while EGCG was not effective at the tested dose.
Supporting Evidence
- Rats treated with resveratrol had significantly fewer tumors per rat compared to controls.
- Resveratrol treatment resulted in a significant delay in the onset of mammary tumors.
- EGCG treatment did not significantly affect tumor incidence or multiplicity.
Takeaway
Feeding rats resveratrol helped them avoid breast cancer, but feeding them EGCG didn't help at all.
Methodology
Female Sprague-Dawley rats were fed diets with resveratrol, EGCG, or a control diet from birth and then treated with DMBA to induce cancer.
Potential Biases
Potential bias in the selection of doses and the specific strains of rats used.
Limitations
The study only tested two polyphenols and did not explore other potential dietary factors.
Participant Demographics
Female Sprague-Dawley CD rats.
Statistical Information
P-Value
0.029
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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