The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor
1999
Galangin: A Flavonoid That Inhibits CYP1A1 Activity
publication
Evidence: moderate
Author Information
Author(s): Ciolino H P, Yeh G C
Primary Institution: National Cancer Institute–Frederick Cancer Research and Development Center
Hypothesis
The dietary flavonoid galangin affects the metabolism of DMBA and the activity of CYP1A1 in breast cancer cells.
Conclusion
Galangin is a potent inhibitor of DMBA metabolism and may serve as an effective chemopreventive agent.
Supporting Evidence
- Galangin inhibited the catabolic breakdown of DMBA in a dose-dependent manner.
- Galangin prevented DMBA-induced inhibition of cell growth.
- Galangin caused a potent, dose-dependent inhibition of CYP1A1 activity.
- Galangin increased the level of CYP1A1 mRNA.
Takeaway
Galangin is a natural compound that helps stop a harmful substance from affecting breast cancer cells.
Methodology
The study investigated the effects of galangin on DMBA metabolism and CYP1A1 activity using MCF-7 human breast carcinoma cells.
Digital Object Identifier (DOI)
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