Study on Sublingual Immunotherapy for Latex Allergy
Author Information
Author(s): Gabriel Gastaminza, Jaime Algorta, Olga Uriel, Maria T Audicana, Eduardo Fernandez, Maria L Sanz, Daniel Munoz
Primary Institution: Department of Allergology, Hospital Santiago-Apostol, Vitoria-Gasteiz, Spain
Hypothesis
The study aims to assess the efficacy and tolerability of latex sublingual immunotherapy in adult patients undergoing permanent latex avoidance.
Conclusion
Further studies are needed to evaluate latex-sublingual immunotherapy, since efficacy could not be demonstrated in adult patients with avoidance of the allergen.
Supporting Evidence
- No significant difference in efficacy was observed between active and placebo groups.
- An improvement in the average percentage of basophils activated was noted.
- Two patients dropped out due to adverse reactions during the maintenance phase.
Takeaway
This study tested a new treatment for people allergic to latex, but it didn't show that the treatment worked better than a placebo.
Methodology
The study was a randomized, double-blind, placebo-controlled trial with 28 adult latex-allergic patients receiving either active treatment or placebo over two years.
Potential Biases
Potential bias due to the subjective nature of patient-reported outcomes and the small sample size.
Limitations
The study had a small sample size and a high dropout rate, which may affect the results.
Participant Demographics
28 adult patients (5 males and 23 females) with a mean age of 39 years.
Statistical Information
Confidence Interval
95% CI: 0.59-13.95
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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