Lipid Profile in HIV-Infected Women on Antiretroviral Therapy
Author Information
Author(s): Estrada Vicente, Geijo Paloma, Fuentes-Ferrer Manuel, Alcalde María Luisa García, Rodrigo María, Galindo María José, Muñoz Agustín, Domingo Pere, Ribera Esteve, Cosín Jaime, Viciana Pompeyo, Lozano Fernando, Terrón Alberto, Vergara Antonio, Teira Ramón, Muñoz-Sánchez Josefa, Roca Bernardino, Sánchez Trinitario, López-Aldeguer José, Deig Elisabeth, Vidal Francisco, Pedrol Enric, Castaño-Carracedo Manuel, Puig Teresa, Garrido Myriam, Suárez-Lozano Ignacio
Primary Institution: Hospital Clínico San Carlos, Madrid, Spain
Hypothesis
What is the lipid profile of HIV-infected women on contemporary antiretroviral therapy?
Conclusion
NNRTI-based ART is associated with a better lipid profile than PI-based ART in HIV-infected women.
Supporting Evidence
- The study included 922 women on stable ART without lipid-lowering treatment.
- Median total cholesterol was 189 mg/dL.
- Patients on NNRTI treatment had significantly higher HDL values.
- HCV-coinfected patients had lower TC/HDL ratios than non-coinfected patients.
Takeaway
This study looked at women with HIV and found that those taking one type of medicine had healthier fats in their blood than those taking another type.
Methodology
Observational, multicentre, cross-sectional study from the Spanish VACH Cohort.
Potential Biases
Under-representation of women in clinical studies may affect generalizability.
Limitations
No information on HCV viral load or specific HCV treatment; potential bias due to exclusion of patients on lipid-lowering treatment.
Participant Demographics
Median age was 42 years; 85.6% had undetectable HIV-1 viral load; 43.8% were HCV-coinfected.
Statistical Information
P-Value
p<0.001
Confidence Interval
CI 95%: 0.001;0.017
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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