Second cancers in children after treatment
Author Information
Author(s): Vathaire F de, Hawkins M, Campbell S, Oberlin O, Raquin M-A, Schlienger J-Y, Shamsaldin A, Diallo I, Bell J, Grimaud E, Hardiman C, Lagrange J-L, Daly-Schveitzer N, Panis X, Zucker J-M, Sancho-Garnier H, Eschwège F, Chavaudra J, Lemerle J
Primary Institution: Research Unit of Cancer Epidemiology (U351 INSERM), Department of Pediatrics, Radiotherapy, Institut Gustave Roussy, Villejuif, France
Hypothesis
The study investigates how different treatments influence the long-term risk of developing solid second malignant neoplasms (SMN) after a first cancer in childhood.
Conclusion
The addition of chemotherapy to radiotherapy increases the risk of solid SMN in children, but does not significantly change how this risk varies over time.
Supporting Evidence
- 113 children developed a solid SMN compared to 12.3 expected from general population rates.
- The relative risk of solid SMN decreased with time after first treatment.
- The excess absolute risk increased during a period of at least 30 years after the first cancer.
Takeaway
Kids who had cancer and got treated might get another type of cancer later, especially if they had chemotherapy along with radiation.
Methodology
The study analyzed a cohort of 4400 patients who were treated for cancer before age 17 and followed them for an average of 15 years, recording their treatment history and estimating radiation doses.
Participant Demographics
Patients were children treated for cancer before the age of 17 years.
Digital Object Identifier (DOI)
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