Anti-angiogenic effect of high doses of ascorbic acid
2008
Effects of High Doses of Vitamin C on Blood Vessel Formation
publication
Evidence: moderate
Author Information
Author(s): Mikirova Nina A, Ichim Thomas E, Riordan Neil H
Primary Institution: Bio-Communications Research Institute, Wichita, Kansas, USA
Hypothesis
High doses of ascorbic acid may exert anti-angiogenic effects.
Conclusion
High concentrations of ascorbic acid inhibit the formation of new blood vessels by affecting endothelial cell functions.
Supporting Evidence
- High concentrations of ascorbic acid suppressed capillary-like tube formation on Matrigel.
- Cell migration was inversely correlated with ascorbic acid concentrations.
- Ascorbic acid inhibited nitric oxide production, which is important for angiogenesis.
Takeaway
Giving a lot of vitamin C can stop the body from making new blood vessels, which is important for healing and cancer growth.
Methodology
The study involved in vitro assays using endothelial progenitor cells and mature endothelial cells to assess the effects of high concentrations of ascorbic acid on cell migration, energy metabolism, and tube formation.
Digital Object Identifier (DOI)
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