Endometrial Histopathology in Women with Salpingitis and HIV-1
Author Information
Author(s): Nelly R. Mugo, Julia Kiehlbauch, Nancy Kiviat, Rosemary Nguti, Joseph W. Gichuhi, Walter E. Stamm, Craig R. Cohen
Primary Institution: Kenyatta National Hospital
Hypothesis
To identify sensitive and specific histological criteria for endometritis in women with laparoscopically-confirmed acute salpingitis.
Conclusion
Endometrial histology did not perform well as a surrogate marker for moderate to severe salpingitis and failed as a surrogate marker for mild salpingitis.
Supporting Evidence
- 38% of women with salpingitis were HIV-1 seropositive.
- Endometrial biopsy specimens were evaluable in 72% of cases.
- Women with severe salpingitis had a higher frequency of PMN and PC per high-power field.
Takeaway
The study looked at how well endometrial tissue samples can help diagnose a condition called salpingitis in women, especially those with HIV. It found that these samples aren't very reliable for diagnosing the condition.
Methodology
Women aged 18-40 with lower abdominal pain underwent clinical examination, HIV screening, and endometrial biopsy, with diagnosis confirmed by laparoscopy.
Potential Biases
Potential bias due to the subjective nature of laparoscopic criteria for mild salpingitis.
Limitations
HIV-1-infected controls did not undergo laparoscopic evaluation, limiting the ability to exclude subclinical salpingitis.
Participant Demographics
Women aged 18-40, with a significant portion being HIV-1 seropositive.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI 1.1–8.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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