Genetic Study of Breast and Prostate Cancer in Framingham
Author Information
Author(s): Murabito Joanne M, Rosenberg Carol L, Finger Daniel, Kreger Bernard E, Levy Daniel, Splansky Greta Lee, Antman Karen, Hwang Shih-Jen
Primary Institution: The National Heart, Lung, and Blood Institute's Framingham Heart Study
Hypothesis
Can genome-wide association studies identify genetic variants associated with breast and prostate cancer risk?
Conclusion
Although no association attained genome-wide significance, several interesting associations emerged for breast and prostate cancer.
Supporting Evidence
- 58 women had breast cancer and 59 men had prostate cancer in the study.
- Two MSR1 SNPs were associated with prostate cancer.
- Three ERBB4 SNPs were associated with breast cancer.
Takeaway
This study looked at genes that might cause breast and prostate cancer in a large group of people, but didn't find any strong links.
Methodology
A genome-wide association study was conducted using Affymetrix 100K SNP GeneChip on participants from the Framingham Heart Study.
Potential Biases
Survival bias may have been introduced due to the enrollment and examination timeline of participants.
Limitations
The study had a small number of cancer events and limited SNP coverage, which may affect the ability to detect associations.
Participant Demographics
The study included 1335 participants from 330 families, with 54% women and a mean entry age of 33 years.
Statistical Information
P-Value
p = 8.0 × 10-8 for breast cancer and p = 1.75 × 10-6 for prostate cancer for the top SNPs.
Digital Object Identifier (DOI)
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