Effects of Fenofibrate and Retinoic Acid on Endometrial Cancer
Author Information
Author(s): Saidi Samir A, Holland Cathrine M, Charnock-Jones D Stephen, Smith Stephen K
Primary Institution: University Department of Obstetrics & Gynaecology, The Rosie Hospital, Cambridge, UK
Hypothesis
Can fenofibrate and retinoic acid inhibit the growth of endometrial cancer cells?
Conclusion
The combination of fenofibrate and retinoic acid significantly inhibits the growth of Ishikawa endometrial cancer cells in vitro.
Supporting Evidence
- Fenofibrate inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells.
- The combination of fenofibrate and retinoic acid caused a greater reduction in cell number than fenofibrate alone.
- High doses of fenofibrate combined with retinoic acid resulted in over 90% reduction in cell number.
Takeaway
This study found that a drug called fenofibrate, when used with another drug called retinoic acid, can help stop cancer cells from growing.
Methodology
The study used in vitro cell culture experiments and in vivo mouse models to assess the effects of fenofibrate and retinoic acid on endometrial cancer cells.
Limitations
The in vivo results were inconsistent and did not show a clear effect on tumor growth.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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