How Schistosoma mansoni Glycoproteins Affect the Immune System
Author Information
Author(s): Sprong Hein, Suchanek Monika, van Dijk Suzanne M, van Remoortere Alexandra, Klumperman Judith, Avram Diana, van der Linden Joke, Leusen Jeanette H. W, van Hellemond Jaap J, Thiele Christoph
Primary Institution: Utrecht University, Netherlands
Hypothesis
The study investigates whether the release of glycoproteins from Schistosoma mansoni contributes to immune evasion.
Conclusion
The transfer of parasite antigens to host cells via lipoproteins disrupts lipid balance in immune cells and may lead to an ineffective immune response.
Supporting Evidence
- Schistosomal glycoproteins were found associated with human lipoprotein particles in infected patients.
- Endocytosis of these glycoproteins by host cells led to changes in lysosome morphology.
- Neutrophils from infected patients showed increased lipid accumulation and apoptosis.
Takeaway
Parasites can hide from our immune system by sticking their proteins to our body's fat carriers, which confuses our immune cells.
Methodology
The study involved isolating lipoprotein particles from patient serum and analyzing the uptake of schistosomal glycoproteins by host cells.
Participant Demographics
Patients suffering from chronic schistosomiasis and control individuals.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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