Crohn's Disease Phenotypes and Their Associations
Author Information
Author(s): Charles N Bernstein, Remo Panaccione, Zoann Nugent, Deborah A Marshall, Gilaad G Kaplan, Stephen Vanner, Levinus A Dieleman, Lesley A Graff, Anthony Otley, Jennifer Jones, Michelle Buresi, Sanjay Murthy, Mark Borgaonkar, Brian Bressler, Alain Bitton, Kenneth Croitoru, Sacha Sidani, Aida Fernandes, Paul Moayyedi
Primary Institution: University of Manitoba
Hypothesis
What are the contemporary presentations and associations of Crohn's disease in Canada?
Conclusion
Inflammatory disease is the main Crohn's disease phenotype in Canada, and surgery related to Crohn's disease remains very common.
Supporting Evidence
- Approximately 2 of every 5 persons with Crohn's disease underwent CD-related surgery.
- Inflammatory disease was the most common phenotype after a mean of 15 years' disease duration.
- Perineal disease was most commonly seen in persons with B3 disease behavior.
Takeaway
This study looked at a lot of people with Crohn's disease in Canada and found that most have a type that causes inflammation, and many need surgery.
Methodology
Participants were adults with Crohn's disease from 14 Canadian centers, assessed for disease phenotype, comorbidities, surgeries, and therapies through chart review.
Potential Biases
Potential bias due to convenience sampling and self-reported data.
Limitations
The majority of participants were white and born in Canada, which may limit the generalizability of the findings.
Participant Demographics
59% female, mean age 44.1 years, 90% white, 90% born in Canada.
Statistical Information
P-Value
P<0.0001
Confidence Interval
95% CI, 2.92-4.93 for B2; 95% CI, 5.69-10.45 for B3
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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