Regulation of endometrial cancer cell growth by luteinizing hormone (LH) and follicle stimulating hormone (FSH)
2000
How Hormones Affect Endometrial Cancer Cells
publication
Author Information
Author(s): Davies S, Bax C M R, Chatzaki E, Chard T, Iles R K
Primary Institution: Williamson Laboratory, East Wing, St Bartholomew's Hospital, London, UK
Hypothesis
Can the suppression of LH and FSH by GnRHa explain tumor regression in endometrial cancer patients?
Conclusion
Luteinizing hormone and follicle stimulating hormone stimulate endometrial cancer cell growth through a non-classical pathway.
Supporting Evidence
- Recombinant human LH and FSH produced a concentration-dependent stimulation of endometrial cancer cells.
- The maximum increase in cell growth was 62% for LH and 50% for FSH compared to untreated controls.
- The Ishikawa cell line showed a maximum growth increase of 67% with LH but not with FSH.
- Neither LH nor FSH elicited cAMP production in the endometrial cancer cell lines.
Takeaway
This study found that certain hormones can help endometrial cancer cells grow, even though they don't work in the usual way.
Methodology
The study examined the effects of recombinant human LH and FSH on endometrial cancer cell lines in serum-free medium.
Digital Object Identifier (DOI)
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