TLR2 in Oral Cancer
Author Information
Author(s): Ng L K, Rich A M, Hussaini H M, Thomson W M, Fisher A L, Horne L S, Seymour G J
Primary Institution: University of Otago
Hypothesis
The study aimed to investigate the expression of toll-like receptor 2 (TLR2) on cells associated with oral squamous cell carcinoma.
Conclusion
The presence of TLR2 in the microenvironment suggests immune activation against altered epithelial cells, while its expression by malignant keratinocytes may indicate resistance to cell death.
Supporting Evidence
- More immune cells expressed TLR2 in carcinoma and dysplasia than in hyperplasia.
- 64% of carcinoma cases and 74% of dysplasia cases showed TLR2 positive keratinocytes.
- Keratinocytes in hyperplastic samples did not show TLR2 expression.
Takeaway
This study found that a protein called TLR2 is more common in cancerous cells than in normal cells, which might help the body fight cancer but also help the cancer survive.
Methodology
The study used immunohistochemistry to analyze TLR2 expression in tissue samples from patients with oral squamous cell carcinoma, epithelial dysplasia, and irritative hyperplasia.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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