Dengue Virus Kinetics in Adults
Author Information
Author(s): Tricou Vianney, Minh Nguyet Nguyen, Farrar Jeremy, Tran Hien Tinh, Simmons Cameron P.
Primary Institution: Oxford University Clinical Research Unit
Hypothesis
Exploring the relationships between virological features of dengue infection and patient immune status may help identify predictors of disease severity.
Conclusion
The early magnitude of viremia is positively associated with disease severity, and the clearance of DENV is influenced by immune status and virus serotype.
Supporting Evidence
- 11.7% of patients had primary dengue fever (DF), while 60.5% had secondary DF.
- DHF was associated with secondary infection with an odds ratio of 3.13.
- DENV-1 infections resulted in significantly higher viremia levels than DENV-2 infections.
- Peak viremias were significantly less often observed during secondary infections than primary.
- The clearance of DENV viremia occurs earlier and faster in patients with secondary dengue.
Takeaway
Dengue can make people very sick, and how much virus is in their blood early on can help doctors understand how bad their illness might get.
Methodology
The study involved a randomized controlled trial of chloroquine in 307 adults with suspected dengue, focusing on clinical features, antibody responses, and virological markers.
Potential Biases
The majority of patients were infected by DENV-1, which may skew the results.
Limitations
The study results may not be representative of all dengue patients as it was conducted in a hospital setting.
Participant Demographics
The study included 307 adults, primarily Vietnamese, with a mix of primary and secondary dengue infections.
Statistical Information
P-Value
0.001
Confidence Interval
95% CI 1.04–12.75
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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