Urinary Hepcidin Level as a Predictor of Iron Deficiency in Children
Author Information
Author(s): Sanad Mohammed, Gharib Amal
Primary Institution: Zagazig University, Egypt
Hypothesis
Can urinary hepcidin-25 levels predict iron deficiency in children before anemia develops?
Conclusion
Urinary hepcidin-25 levels can predict iron deficiency very early, before any hematological issues arise.
Supporting Evidence
- Urinary hepcidin levels were significantly lower in all stages of iron deficiency compared to healthy controls.
- Three cutoff points for urinary hepcidin were established to differentiate between stages of iron deficiency.
- The study suggests urinary hepcidin could be a simple and non-invasive test for early detection of iron deficiency.
Takeaway
This study found that measuring a substance called hepcidin in urine can help doctors tell if kids are low on iron before they get sick.
Methodology
A case control study with 100 children, including 75 with varying stages of iron deficiency and 25 healthy controls.
Limitations
The study had a small number of cases and was limited to a single center.
Participant Demographics
Children aged around 5 years, with a mix of genders.
Statistical Information
P-Value
p<0.001
Confidence Interval
(0.707-0.927), (0.840-0.988), (0.927-1.000)
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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