Combining Temozolomide and Procarbazine for Gliomas
Author Information
Author(s): Newlands E S, Foster T, Zaknoen S
Primary Institution: Imperial College School of Medicine
Hypothesis
Does combining procarbazine with temozolomide increase the therapeutic index in treating malignant gliomas?
Conclusion
The combination of temozolomide and procarbazine is a reasonably effective and well-tolerated treatment for patients with relapsed gliomas.
Supporting Evidence
- The overall response rate to the combination treatment was 36%.
- Responses were seen in all types of glioma.
- The combination was well tolerated at doses up to level 3.
Takeaway
This study tested a new medicine combination to help people with brain tumors, and it seems to work pretty well without causing too many problems.
Methodology
28 patients with malignant gliomas were treated with temozolomide and escalating doses of procarbazine, assessing responses clinically and radiologically.
Limitations
The study was limited by a small sample size and the interruption of procarbazine supply.
Participant Demographics
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Digital Object Identifier (DOI)
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