Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice
2011
MDMA and Its Effects on Body Temperature in Parkin Knockout Mice
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): Takamatsu Y, Shiotsuki H, Kasai S, Sato S, Iwamura T, Hattori N, Ikeda K
Primary Institution: Tokyo Institute of Psychiatry
Hypothesis
Parkin protects against neurotoxic insult from MDMA-induced hyperthermia.
Conclusion
MDMA-induced hyperthermia was enhanced in parkin knockout and heterozygous mice compared to wildtype mice.
Supporting Evidence
- MDMA significantly enhances hyperthermia in parkin knockout mice.
- Baseline body temperature was similar across all genotypes.
- Parkin is hypothesized to protect DA neurons from MDMA-induced toxicity.
Takeaway
When mice without the parkin gene were given MDMA, they got much hotter than normal mice, showing that parkin helps protect against the harmful effects of MDMA.
Methodology
Body temperature was measured rectally before and after MDMA injection in different mouse genotypes.
Participant Demographics
Mice were wildtype, heterozygous, and homozygous parkin knockout, aged 12-29 weeks.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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