The Role of DSCC1 in Breast Cancer Prognosis
Author Information
Author(s): Aljohani Abrar I.
Primary Institution: Taif University
Hypothesis
This research aimed to explore the prognostic significance of DSCC1 in invasive breast cancer and its association with aggressive tumor behavior.
Conclusion
The study confirmed that high expression of DSCC1 is associated with poor outcomes in invasive breast cancer patients.
Supporting Evidence
- High DSCC1 expression was significantly associated with high histological grade and large tumor size.
- High DSCC1 mRNA levels correlated with poor patient outcomes in both METABRIC and TCGA cohorts.
- High DSCC1 protein expression was linked to shorter survival in invasive breast cancer patients.
Takeaway
This study found that a protein called DSCC1 can help predict how aggressive breast cancer is, which can guide treatment decisions.
Methodology
The study assessed DSCC1 expression at the mRNA level in two large cohorts (METABRIC and TCGA) and at the protein level in a cohort of 100 invasive breast cancer patients using immunohistochemistry.
Limitations
The sample size for the proteomic analysis was limited to 100 patients.
Participant Demographics
The study included breast cancer patients from Saudi Arabia, with a focus on various clinicopathological features.
Statistical Information
P-Value
p<0.001 for METABRIC, p=0.022 for TCGA
Confidence Interval
95% CI 1.098–1.599
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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