Modulation of the transcription regulatory program in yeast cells committed to sporulation
2006
How Yeast Cells Control Their Gene Expression During Sporulation
publication
Evidence: high
Author Information
Author(s): Friedlander Gilgi, Joseph-Strauss Daphna, Carmi Miri, Zenvirth Drora, Simchen Giora, Barkai Naama
Primary Institution: Weizmann Institute of Science
Hypothesis
Commitment to sporulation involves an active modulation of the gene expression program.
Conclusion
Cells ensure commitment to sporulation by actively modulating their gene-expression program rather than stabilizing the process.
Supporting Evidence
- The majority of genes induced during sporulation were repressed upon transfer to growth medium.
- Committed cells displayed a unique transcriptional response to nutrients.
- The study identified over 1,000 genes whose expression changed significantly during sporulation.
Takeaway
Yeast cells change how they express their genes when they start to make spores, making sure they can adapt to their environment.
Methodology
The study used DNA microarrays to analyze gene expression in yeast cells at different stages of sporulation.
Digital Object Identifier (DOI)
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