Metabolomic Study of Cloned Pigs
Author Information
Author(s): Morten R. Clausen, Kirstine L. Christensen, Mette S. Hedemann, Ying Liu, Stig Purup, Mette Schmidt, Henrik Callesen, Jan Stagsted, Hanne C. Bertram
Primary Institution: Aarhus University
Hypothesis
A cloned animal model would be beneficial for intervention studies due to expected lower inter-individual variation.
Conclusion
Cloned and normal outbred pigs are phenotypically different, but cloned pigs do not show reduced inter-individual variation.
Supporting Evidence
- Cloned pigs had higher plasma lactate levels compared to control pigs.
- Differences in bile composition were observed between cloned and control pigs.
- The study used NMR spectroscopy to analyze multiple bio-fluids.
Takeaway
Scientists studied cloned pigs to see if they are more similar to each other than regular pigs, but found they are still different.
Methodology
NMR-based metabolomic analysis of plasma, bile, and urine from cloned and control pigs.
Limitations
The study was based on a limited number of animals.
Participant Demographics
5 cloned pigs and 6 normal outbred pigs.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website