Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target
2009
Angiostatin's Role in Immune System and Angiogenesis
Sample size: 13
publication
Evidence: high
Author Information
Author(s): Adriana Albini, Claudio Brigati, Agostina Ventura, Girieca Lorusso, Marta Pinter, Monica Morini, Alessandra Mancino, Antonio Sica, Douglas M Noonan
Primary Institution: IRCCS Multimedica, Milan, Italy
Hypothesis
IL-12 is the mediator of angiostatin's anti-angiogenic activity.
Conclusion
Angiostatin acts on innate immune cells as key targets in inflammatory angiogenesis.
Supporting Evidence
- Angiostatin inhibits angiogenesis induced by VEGF-TNFα or supernatants of Kaposi's Sarcoma cells.
- Function-blocking antibodies to IL-12 reverted angiostatin-induced angiogenesis inhibition.
- Angiostatin induces IL-12 mRNA synthesis by human macrophages in vitro.
Takeaway
Angiostatin helps stop the growth of new blood vessels by working with the immune system, especially a helper called IL-12.
Methodology
In vivo studies using the subcutaneous matrigel model of angiogenesis and quantitative real-time PCR.
Participant Demographics
CD1 nude mice were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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