Liuweizhiji Gegen-Sangshen Beverage Protects Against Alcoholic Liver Disease in Mice
Author Information
Author(s): Tang Mingyun, Zhao Long, Huang Fuchun, Wang Tiangang, Wu Xu, Chen Shanshan, Fu Juan, Jiang Chaoli, Wei Shulin, Zeng Xuseng, Zhang Xiaoling, Zhou Xin, Wei Mei, Li Zhi, Xiao Guohui
Primary Institution: Southwest Medical University, Luzhou, Sichuan, China
Hypothesis
Liuweizhiji Gegen-Sangshen beverage may impact the gut microbiota, trigger host response, and alleviate alcoholic liver disease (ALD).
Conclusion
Liuweizhiji Gegen-Sangshen beverage significantly protects against alcoholic liver disease in mice by modulating gut microbiota and enhancing the SCFAs/GPR43/GLP-1 pathway.
Supporting Evidence
- LGS treatment reduced liver injury and inflammation in ALD mice.
- LGS improved liver steatosis and enhanced alcohol metabolism.
- LGS modulated gut microbiota structure in ALD mice.
- LGS increased production of short-chain fatty acids, particularly hexanoic acid.
- LGS activated the GPR43/GLP-1 pathway, improving liver health.
- LGS showed comparable effects to the positive drug MTDX in several indices.
- LGS maintained intestinal barrier function by increasing occludin expression.
- LGS treatment resulted in a significant reduction in the Firmicutes to Bacteroidetes ratio.
Takeaway
This study shows that a special herbal drink can help mice with liver problems caused by drinking too much alcohol by changing the bacteria in their gut.
Methodology
An ALD murine model was established using the Lieber-DeCarli alcohol liquid diet, and mice were treated with different doses of Liuweizhiji Gegen-Sangshen beverage.
Limitations
The study primarily focused on early stages of alcoholic liver disease and requires further validation of specific mechanisms.
Participant Demographics
72 male C57BL/6J mice aged 6 to 8 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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