Metallothionein 1E mRNA is highly expressed in oestrogen receptor-negative human invasive ductal breast cancer
2000
High Expression of Metallothionein 1E in Certain Breast Cancers
Sample size: 51
publication
Evidence: moderate
Author Information
Author(s): Jin R, Bay B H, Chow V T K, Tan P H, Lin V C L
Primary Institution: National University of Singapore
Hypothesis
MT-1E mRNA expression differs between oestrogen receptor-positive and oestrogen receptor-negative breast cancer tissues.
Conclusion
MT-1E mRNA is significantly more expressed in oestrogen receptor-negative breast cancer tissues compared to oestrogen receptor-positive tissues.
Supporting Evidence
- MT-1E mRNA expression was significantly higher in oestrogen receptor-negative breast cancer tissues.
- MCF7 cells, which are oestrogen receptor-positive, did not express MT-1E mRNA.
- Both oestrogen receptor-negative and progesterone receptor-negative MDA-MB-231 cells showed high levels of MT-1E mRNA.
Takeaway
This study found that a specific protein, Metallothionein 1E, is found in higher amounts in a type of breast cancer that doesn't respond to certain hormones.
Methodology
Semi-quantitative RT-PCR was used to evaluate MT-1E mRNA expression in breast cancer tissues and cell lines.
Statistical Information
P-Value
0.026
Statistical Significance
p=0.026
Digital Object Identifier (DOI)
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