Identifying High-Risk Areas for Neonatal Mortality from Bacterial Sepsis
Author Information
Author(s): Costa-Nobre Daniela Testoni, Marinonio Ana Sílvia Scavacini, Miyoshi Milton Harumi, Sanudo Adriana, Areco Kelsy Catherina Nemo, Kawakami Mandira Daripa, Balda Rita de Cássia Xavier, Konstantyner Tulio, Vieira e Oliveira Carina Nunes, Bandiera-Paiva Paulo, de Freitas Rosa Maria Vieira, Teixeira Monica La Porte, Waldvogel Bernadette, de Almeida Maria Fernanda, Guinsburg Ruth, Kiffer Carlos Roberto Veiga
Primary Institution: Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
Hypothesis
Our aim was to identify high-risk areas of neonatal mortality associated with bacterial sepsis in the state of São Paulo, Brazil.
Conclusion
The study found that neonatal deaths associated with bacterial sepsis were not randomly distributed, with high-risk clusters identified mainly in the southeast region of São Paulo.
Supporting Evidence
- The study identified a prevalence of neonatal death associated with bacterial sepsis of 2.3 per 1000 live births.
- Clusters of high neonatal mortality were found mainly in the southeast region of São Paulo.
- The analysis included data from over 9 million live births.
Takeaway
The study looked at where babies are most likely to die from a serious infection called sepsis, and found specific areas in Brazil where this happens more often.
Methodology
A population-based study using retrospective spatial scan statistics with data from birth and death certificates.
Potential Biases
Subjectivity in parameter selection might induce bias or lead to misinterpretation.
Limitations
The methodology may miss clusters that do not fit predefined windows and is subject to data quality issues.
Participant Demographics
The study included live births from mothers residing in São Paulo State from 2004 to 2020, with a focus on neonatal deaths associated with bacterial sepsis.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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