False HbA1c Value Due to Unusual Hemoglobin Variant
Author Information
Author(s): Esperanza Lepe Balsalobre, Gema María Varo Sánchez, Marta Rico Rodríguez, Sandra Fuentes Cantero
Primary Institution: Servicio de Laboratorio Área de Gestión Sanitaria Norte de Huelva, Hospital de Riotinto, Minas de Riotinto, Huelva, España
Hypothesis
Can the unusual hemoglobin variant Hb Petie Salpetriere interfere with HbA1c analysis?
Conclusion
The Hb Petie Salpetriere variant can interfere with HbA1c results from ion-exchange HPLC but not with latex agglutination immunoassays.
Supporting Evidence
- The HbA1c levels were discordant between HPLC and immunoassay methods.
- This is the first reported case of the Hb Petie Salpetriere variant in Spain.
- The variant was identified through meticulous review of the chromatogram.
Takeaway
A 78-year-old patient had a false high HbA1c reading due to a rare hemoglobin variant, which was only detected through careful analysis.
Methodology
The study involved HPLC analysis for HbA1c and genetic sequencing to identify the hemoglobin variant.
Limitations
The study is based on a single case, limiting the generalizability of the findings.
Participant Demographics
One 78-year-old male patient with a history of hypertension and dyslipidemia.
Digital Object Identifier (DOI)
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