Intratumoral Lactobacillus iners as a poor prognostic biomarker and potential therapeutic target for cervical cancer
2024
Lactobacillus iners and Cervical Cancer
publication
Evidence: moderate
Author Information
Author(s): Liu Yang, Cao Lei
Primary Institution: Wuxi People’s Hospital, Nanjing Medical University
Hypothesis
Can Lactobacillus iners serve as a prognostic biomarker and therapeutic target for cervical cancer?
Conclusion
Lactobacillus iners in cervical cancer tumors is linked to poor prognosis and resistance to treatment.
Supporting Evidence
- Lactobacillus iners can induce resistance to chemotherapy in cervical cancer.
- Patients with L. iners in their tumors have poorer recurrence-free survival.
- L. iners produces L-lactate, which affects tumor metabolism and treatment response.
Takeaway
Lactobacillus iners is a type of bacteria that can make cervical cancer worse, but scientists think it could also help create new treatments.
Methodology
The study involved analyzing tumor microbiome sequencing and examining the metabolic effects of Lactobacillus iners on cervical cancer cells.
Limitations
Further validation studies are needed to confirm the findings across diverse patient populations.
Digital Object Identifier (DOI)
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