EBV-Associated Smooth Muscle Neoplasms in Immunocompromised Patients
Author Information
Author(s): Kimberly Moore Dalal, Cristina R. Antonescu, Ronald P. DeMatteo, Robert G. Maki
Primary Institution: Memorial Sloan-Kettering Cancer Center
Hypothesis
To report experiences with EBV-related neoplasms and describe the first EBV-related smooth muscle neoplasm in patients receiving immunosuppressive therapy.
Conclusion
EBV-related smooth muscle neoplasms have variable aggressiveness, and improving the host immune status provides the best opportunity for tumor control.
Supporting Evidence
- Patients who reduced immunosuppression survived longer.
- Surgical resection or chemotherapy delayed disease progression.
- EBV is associated with smooth muscle neoplasms in immunocompromised patients.
Takeaway
Some people with weak immune systems can get rare tumors caused by a virus called EBV, and treating the immune system can help control these tumors.
Methodology
Case reports with a minimum 3-year follow-up from 2002 to 2005, involving surgical resection and chemotherapy.
Limitations
Relatively short follow-up for these slow-growing neoplasms.
Participant Demographics
Three patients with different causes of immune dysregulation: one with a renal transplant, one with AIDS, and one with psoriasis.
Digital Object Identifier (DOI)
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