Effects of Ginseng and Licorice Extracts on Liver Cancer Cells
Author Information
Author(s): David G. Popovich, Yeo Shi Yun, Zhang Wei
Primary Institution: National University of Singapore
Hypothesis
Do combinations of American ginseng and licorice extracts affect the viability of hepatocarcinoma cells synergistically or antagonistically?
Conclusion
The combination of ginseng and licorice extracts was found to have an antagonistic effect on the viability of Hep-G2 cells.
Supporting Evidence
- Both ginseng and licorice extracts reduced Hep-G2 cell viability independently.
- All combinations of ginseng and licorice extracts showed antagonistic effects.
- LC50 values for ginseng and licorice were determined to be 0.64 mg/mL and 0.53 mg/mL, respectively.
- Cell-cycle analysis indicated a significant arrest at the G1 phase for licorice extract.
- Lactate dehydrogenase release increased with higher proportions of ginseng in the mixtures.
Takeaway
Mixing ginseng and licorice extracts doesn't help liver cancer cells; instead, it makes them survive better.
Methodology
Isobolographic analysis was used to assess the interaction between ginseng and licorice extracts on Hep-G2 cell viability.
Limitations
The study focused only on Hep-G2 cells and may not be applicable to other cell types.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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