Reply: “Comorbidity between epilepsy and headache/migraine: the other side of the same coin!”
2011
Reply on Comorbidity between Epilepsy and Headache/Migraine
Commentary
Author Information
Author(s): Irene Toldo, Pier Antonio Battistella
Primary Institution: Department of Pediatrics, Juvenile Headache Center, University of Padua
Conclusion
Further studies are necessary to clarify the pathophysiological mechanisms of the association between headache/migraine and epilepsy.
Supporting Evidence
- Neuronal hyperexcitability and increased susceptibility to cortical spreading depression are key mechanisms linking headaches and epilepsy.
- Large, well-phenotyped samples are needed to discover genetic factors involved in the comorbidity of headache/migraine and epilepsy.
- Clinical markers may help select more homogeneous patient populations for genotype analysis.
Takeaway
This article discusses how headaches and epilepsy can be related and suggests that more research is needed to understand why they occur together.
Digital Object Identifier (DOI)
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