Correlation of oncoprotein 18/stathmin expression in human breast cancer with established prognostic factors
2000
Correlation of oncoprotein 18/stathmin expression in human breast cancer with established prognostic factors
Sample size: 151
publication
Author Information
Author(s): Brattsand G
Primary Institution: Department of Clinical Chemistry, Umeå University Hospital, Umeå, Sweden
Hypothesis
The study investigates the correlation between Op18 expression and clinicopathologic characteristics in breast cancer.
Conclusion
High Op18 expression correlates with general predictive factors in breast cancer, contrary to previous reports.
Supporting Evidence
- Op18 levels were negatively correlated with oestrogen receptor expression.
- Op18 levels were positively correlated with a high fraction of aneuploid cells.
- Op18 levels were positively correlated with proliferation measured by PCNA expression.
- Op18 levels were positively correlated with tumour size.
- Op18 levels were positively correlated with histopathologic grade.
Takeaway
This study found that a protein called Op18 is linked to important factors in breast cancer, showing it might be important for understanding the disease.
Methodology
Quantitative Western blot analysis was used to examine Op18 protein expression in breast carcinoma samples.
Digital Object Identifier (DOI)
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