Placental Transfer of Lactate and Glucose in Diabetic Rats
Author Information
Author(s): CHRIS R. THOMAS, BERYL B. OON, CLARA LOWY
Primary Institution: Department of Medicine, Guys Kings and St. Thomas School of Medicine, St. Thomas' Hospital, London, UK
Hypothesis
Can maternal glucose be the source of lactate in the fetal circulation of normal and diabetic pregnant rats?
Conclusion
Placental glucose transport is less efficient in diabetic animals, but the higher maternal glucose concentration compensates for this, resulting in similar fetal glucose uptake between groups.
Supporting Evidence
- Maternal weight, litter size, and fetal weight were significantly reduced in diabetic rats compared to controls.
- Fetal plasma lactate concentrations were significantly higher in diabetic animals compared to controls.
- The placenta did not secrete significant quantities of lactate in this experimental model.
Takeaway
This study looked at how glucose and lactate move from mother to baby in rats, finding that even though diabetic mothers had higher glucose levels, the babies got about the same amount of glucose as those from healthy mothers.
Methodology
The study used an in situ perfused placenta model with control and diabetic Wistar rats to measure the transfer of glucose and lactate.
Limitations
The study was conducted on a specific rat model, which may not fully represent human physiology.
Participant Demographics
Wistar rats, both control and diabetic groups.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website