Effects of Descending Positive End-Expiratory Pressure on Lung Mechanics in Healthy Piglets
Author Information
Author(s): Alysson Roncally Carvalho, Frederico C. Jandre, Alexandre V. Pino, Fernando A. Bozza, Jorge I. Salluh, Rosana S. Rodrigues, João H. N. Soares, Antonio Giannella-Neto
Primary Institution: Federal University of Rio de Janeiro
Hypothesis
This study sought to evaluate the potential usefulness of monitoring elastance of the respiratory system (Ers) to set the PEEP to prevent tidal recruitment and hyperinflation in healthy lungs under general anaesthesia.
Conclusion
In healthy piglets, the PEEP at minimum Ers maximized normally aerated areas while minimizing tidal re-aeration and hyperinflation.
Supporting Evidence
- High levels of PEEP reduced tidal re-aeration but increased hyperinflation.
- PEEP titration from 16 to 0 cmH2O showed significant changes in lung aeration.
- Elastance of the respiratory system (Ers) was minimized between 4 and 8 cmH2O of PEEP.
Takeaway
When doctors use a special breathing technique on healthy piglets, they found a way to keep their lungs working better without causing too much pressure.
Methodology
PEEP titration was performed from 16 to 0 cmH2O, and CT scans were obtained to assess lung aeration in healthy, anaesthetized piglets.
Limitations
The lung morphological analysis was based on a single slice of the CT scan, which may not represent the entire lung.
Participant Demographics
Six mixed-breed female Landrace/Large White piglets, weighing 17 to 20 kg.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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