Progestagens for granulosa cell tumours of the ovary
1992
Progestagens for Granulosa Cell Tumours of the Ovary
Sample size: 2
publication
Evidence: low
Author Information
Author(s): R. Isaacs, G. Forgeson, S. Allan
Primary Institution: Radiotherapy and Medical Oncology Department, Palmerston North Hospital
Hypothesis
Can progestagens induce tumor regression in advanced cases of granulosa cell tumors?
Conclusion
Progestagens can induce tumor regression in advanced cases of granulosa cell tumors.
Supporting Evidence
- Case 1 showed complete remission after treatment with MPA.
- Case 2 achieved complete remission after chemotherapy and later responded to Megestrol Acetate.
Takeaway
Two women with advanced ovarian tumors got better after taking progestagens, showing these drugs might help when surgery isn't an option.
Methodology
Case studies of two women treated with progestagens after surgery and chemotherapy.
Limitations
Limited sample size and lack of historical histology for one case.
Participant Demographics
Both participants were multiparous women aged 62 and 68.
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