Effects of Low Dose Radioactive Iodine on Hyperthyroid Patients
Author Information
Author(s): Sundaram P., Shanmuga Padma S., Sudha S., Sasikala K.
Primary Institution: Amrita Institute of Medical Sciences
Hypothesis
The study aimed to investigate the cytotoxic effects of low dose 131I therapy in hyperthyroid patients.
Conclusion
The cytogenetic damage induced by low dose 131I therapy was minimal and reversible.
Supporting Evidence
- A significant increase in chromosomal aberrations was observed on day 7 post-therapy.
- Mean levels of chromosomal aberrations decreased on day 30 post-therapy.
- Control groups showed fewer micronuclei and chromosomal aberrations compared to treated patients.
Takeaway
Doctors use a special type of medicine called radioactive iodine to help people with thyroid problems, and it doesn't hurt them much.
Methodology
The study analyzed peripheral blood lymphocytes for chromosomal aberrations and micronuclei in hyperthyroid patients before and after treatment.
Limitations
The study did not account for all variables affecting treatment outcomes, such as patient characteristics and prior treatments.
Participant Demographics
32 hyperthyroid patients (14 males, 18 females) aged 23-61 years, mean age 49 ± 7 years.
Statistical Information
Statistical Significance
p>0.05
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