Faecal occult blood screening and reduction of colorectal cancer mortality: a case-control study
1999

Screening for Colorectal Cancer Reduces Deaths

publication Evidence: moderate

Author Information

Author(s): Faivre J, Tazi M A, ElMrini T, Lejeune C, Benhamiche A M, Dassonville F

Primary Institution: Registre Bourguignon des Cancers Digestifs, Faculté de Médecine, Dijon Cedex, France

Hypothesis

Does screening with faecal occult blood tests reduce mortality from colorectal cancer?

Conclusion

Screening for colorectal cancer with faecal occult blood tests can significantly reduce mortality rates.

Supporting Evidence

  • Cases were less likely to have been screened than controls, with an odds ratio of 0.67.
  • The odds ratio of death from colorectal cancer was 0.64 for those screened within 3 years of diagnosis.
  • There was a negative association between the risk of death and the number of participations in screening campaigns.

Takeaway

If people get tested for colorectal cancer using a special stool test, they are less likely to die from it.

Methodology

A population-based case-control study comparing screening rates in colorectal cancer cases and matched controls.

Participant Demographics

Participants were individuals born between 1914 and 1943 who died of colorectal cancer diagnosed between 1988 and 1994.

Statistical Information

Confidence Interval

95% CI 0.48–0.94

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1038/sj.bjc.6690107

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