INVESTIGATION OF TRANSCRIPTIONAL CHANGES IN IMMUNE CELL POPULATIONS OF MICE TREATED WITH RAPAMYCIN
2024
Investigating Immune Cell Changes in Mice Treated with Rapamycin
Sample size: 6
publication
Author Information
Author(s): Yousefzadeh Matt
Primary Institution: Columbia University Medical Center
Hypothesis
Rapamycin is able to restore function to aged T cells and possibly other immune cell types.
Conclusion
Rapamycin treatment may rejuvenate aged immune systems, but the specific immune cell populations that benefit are still being studied.
Supporting Evidence
- Rapamycin has been shown to extend lifespan in mice.
- Treatment with rapamycin enhanced antibody responses in elderly humans.
- Single-nuclei RNA sequencing is being used to analyze gene expression changes.
Takeaway
This study looks at how a drug called rapamycin might help older mice have healthier immune systems.
Methodology
18-month-old mice were fed chow with rapamycin or control chow for 7 months, and their spleens were analyzed for gene expression changes.
Participant Demographics
18-month-old WT C57BL/6 mice and 5-month-old young control mice.
Digital Object Identifier (DOI)
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