Multidrug Resistance Genes in Human Cancer
Author Information
Author(s): K. Nooter, H. Herweijer
Primary Institution: Institute of Applied Radiobiology and Immunology TNO; Rotterdam Cancer Center
Hypothesis
The clinical observation of resistance to multidrug-based chemotherapy is due to enhanced mdrl expression in resistant tumors.
Conclusion
The study provides an overview of the expression of multidrug resistance genes in human tumors and their implications for chemotherapy resistance.
Supporting Evidence
- High mdrl expression levels are frequently found in tumors that developed from tissues normally expressing intermediate to high mdrl levels.
- Controversial reports on mdrl expression levels can be attributed to methodological differences.
- Studies have shown that elevated mdrl expression can occur in tumors and that specific agents can circumvent MDR.
Takeaway
Some cancer cells can become resistant to drugs, making treatment less effective. This study looks at how certain genes in these cells might cause that resistance.
Methodology
The study reviewed literature on mdrl expression in human tumors and discussed various detection methods.
Potential Biases
Contamination with non-tumor cells in biopsy samples may affect results.
Limitations
The study notes that many techniques used may not accurately reflect the heterogeneity of tumor cell populations.
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