Van Gogh and Frizzled Work Together to Guide Cell Division in Drosophila
Author Information
Author(s): José-Eduardo Gomes, Maria Corado, François Schweisguth, Hiromu Tanimoto
Primary Institution: Ecole Normale Supérieure, CNRS UMR8542, Paris, France
Hypothesis
How do the proteins Van Gogh and Frizzled contribute to the orientation of asymmetric cell division in Drosophila sensory organ precursor cells?
Conclusion
Van Gogh and Frizzled act redundantly to orient the polarity axis of dividing sensory organ precursor cells in response to local cues.
Supporting Evidence
- Van Gogh and Frizzled are essential for the proper orientation of cell division.
- Dishevelled restricts the localization of centrosome-attracting activity to the anterior cortex.
- Both Van Gogh and Frizzled can influence the orientation of neighboring cells.
Takeaway
This study shows that two proteins, Van Gogh and Frizzled, help cells divide in a specific direction, which is important for their development.
Methodology
The study used genetic and live imaging analyses to investigate the roles of Van Gogh, Frizzled, and Dishevelled in orienting the polarity of sensory organ precursor cells.
Potential Biases
Potential bias in genetic interpretations due to reliance on specific mutant strains.
Limitations
The study primarily focuses on Drosophila and may not directly translate to other organisms.
Participant Demographics
Drosophila melanogaster (fruit flies) were used as the model organism.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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