Low-level gestational lead exposure increases retinal progenitor cell proliferation and rod photoreceptor and bipolar cell neurogenesis in mice
2011
Effects of Low Lead Levels on Mice Retina
publication
Author Information
Author(s): Giddabasappa A, Hamilton WR, Chaney S, Xiao W, Johnson JE, Mukherjee S
Hypothesis
Does low-level gestational lead exposure affect retinal development in mice?
Conclusion
Low-level gestational lead exposure increases retinal progenitor cell proliferation and the number of rods and bipolar cells in mice.
Supporting Evidence
- Gestational lead exposure in mice led to an increase in retinal progenitor cells.
- The study found a U-shaped dose-response curve for lead exposure.
- Other studies have shown similar biphasic dose-response relationships for lead.
Takeaway
When pregnant mice are exposed to low levels of lead, their babies may have more special cells in their eyes that help them see better.
Digital Object Identifier (DOI)
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