IGF1R VARIANT R407H PREVENTS COGNITIVE IMPAIRMENT AND NEUROINFLAMMATION IN CRISPR MICE WITH AAV AB42 AND PTAU
2024
IGF1R Variant R407H and Its Effects on Cognitive Impairment
Sample size: 14
publication
Evidence: moderate
Author Information
Author(s): Park Joo Young, Wezeman Jackson, Mangalindan Ruby Sue, Ladiges Warren
Primary Institution: University of Washington
Hypothesis
Can the IGF1R variant R407H prevent cognitive impairment and neuroinflammation in mice with Alzheimer's disease pathology?
Conclusion
Mice with the IGF1R variant showed better cognitive performance and reduced inflammation compared to wild type mice.
Supporting Evidence
- Mice with the IGF1R variant performed better in spatial navigation tasks.
- RNA sequencing showed significant downregulation of inflammatory cytokines.
Takeaway
Scientists studied mice to see if a special gene variant could help them think better and reduce brain inflammation related to Alzheimer's.
Methodology
C57BL/6 mice were injected with AAV9-PHP.eb and tested for cognition after 11 weeks.
Participant Demographics
14 female mice, aged 25 to 28 months.
Statistical Information
P-Value
< 0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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