Risk Factors for 19A Pneumococcal Carriage in Young Children
Author Information
Author(s): Robert Cohen, Corinne Levy, Eric Bonnet, Franck Thollot, Michel Boucherat, Bernard Fritzell, Véronique Derkx, Edouard Bingen, Emmanuelle Varon
Primary Institution: Department of Microbiology, CHI Créteil
Hypothesis
What factors are related to the carriage of serotype 19A in children after the introduction of the 7-valent pneumococcal vaccine?
Conclusion
Antibiotic exposure, daycare attendance, and acute otitis media are linked to 19A carriage in young children.
Supporting Evidence
- Serotype 19A was found in 10.4% of the overall population.
- 20.5% of S. pneumoniae carriers had serotype 19A.
- 40.8% of penicillin non-susceptible carriers had serotype 19A.
- Recent antibiotic use was a significant predictor of 19A carriage.
Takeaway
This study found that kids who take antibiotics, go to daycare, or have ear infections are more likely to carry a certain type of bacteria called 19A.
Methodology
Children aged 6 to 24 months were swabbed for nasopharyngeal samples, and factors influencing pneumococcal carriage were analyzed using logistic regression.
Potential Biases
Potential bias due to the exclusion of children who had received antibiotics recently or had severe health issues.
Limitations
The study's homogeneity makes it difficult to generalize findings to other populations.
Participant Demographics
Children aged 6 to 24 months, predominantly vaccinated with PCV7, with a mean age of 13.6 months.
Statistical Information
Confidence Interval
[1.42;2.30]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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