Androgen Regulation of Coregulators in Prostate Cancer
Author Information
Author(s): Alfonso Urbanucci, Kati K Waltering, Hanna E Suikki, Merja A Helenius, Tapio Visakorpi
Primary Institution: Institute of Medical Technology, University of Tampere and Tampere University Hospital
Hypothesis
The study aims to identify coregulators whose expression is regulated by androgens and/or by the expression level of the androgen receptor (AR).
Conclusion
The study identified five coregulators whose expression is significantly induced by androgens, suggesting they could enhance AR signaling.
Supporting Evidence
- Five coregulators showed more than 2-fold induction by androgens.
- Overexpression of AR enhanced the expression of certain coregulators in response to low levels of androgens.
- Statistical analysis indicated significant changes in coregulator expression in response to DHT.
Takeaway
This study looked at how certain proteins that help the androgen receptor work are affected by androgens, finding that some proteins are turned on more when androgens are present.
Methodology
The study used LNCaP cells transfected with AR cDNA and measured the expression of 25 AR coregulators using Q-RT-PCR after treatment with dihydrotestosterone (DHT).
Statistical Information
P-Value
p < 0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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