Interleukin-1beta Gene and Schizophrenia in Japan
Author Information
Author(s): Sasayama Daimei, Hori Hiroaki, Teraishi Toshiya, Hattori Kotaro, Ota Miho, Iijima Yoshimi, Tatsumi Masahiko, Higuchi Teruhiko, Amano Naoji, Kunugi Hiroshi
Primary Institution: National Center of Neurology and Psychiatry, Japan
Hypothesis
Is there an association between the interleukin-1beta gene and schizophrenia in a Japanese population?
Conclusion
The study provides evidence that the IL-1β gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population, particularly in females.
Supporting Evidence
- Significant difference in allele distribution was found for rs1143633 between patients and controls.
- The C allele of rs1143633 was more common in patients with schizophrenia.
- Significant association was observed in females for rs1143633.
- A trend towards association was found for rs16944 in female patients.
Takeaway
This study found that a specific gene related to inflammation might make some people more likely to develop schizophrenia, especially women.
Methodology
The study examined five tagging polymorphisms of the IL-1β gene in 533 patients with schizophrenia and 1136 healthy controls.
Potential Biases
Potential sample bias due to population stratification.
Limitations
The ethnicity of participants was based on self-reports and not confirmed by genetic analyses, and structured interviews for diagnosis were not used.
Participant Demographics
533 patients (302 males, 233 females) and 1136 healthy controls (388 males, 748 females), all biologically unrelated Japanese individuals.
Statistical Information
P-Value
0.0089
Confidence Interval
1.05 to 1.41
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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