4-Methyl-5-phenyl-1H-pyrazol-3(2H)-one
2011
Study of 4-Methyl-5-phenyl-1H-pyrazol-3(2H)-one
publication
Evidence: moderate
Author Information
Author(s): Loh Wan-Sin, Fun Hoong-Kun, Ragavan R. Venkat, Vijayakumar V., Sarveswari S.
Primary Institution: Universiti Sains Malaysia
Hypothesis
The compound undergoes enol-to-keto tautomerism during the crystallization process.
Conclusion
The study reveals that the compound exists in the keto form and exhibits specific bond lengths indicative of tautomerism.
Supporting Evidence
- The compound contains two crystallographically independent molecules with similar geometries.
- The C=O bond lengths indicate tautomerism during crystallization.
- Intermolecular hydrogen bonds link neighboring molecules into dimers.
Takeaway
This study looks at a chemical compound and how it changes form when it crystallizes, showing that it can switch between two shapes.
Methodology
The compound was synthesized using a literature method and recrystallized from ethanol-chloroform.
Digital Object Identifier (DOI)
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